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KMID : 0617319920020010017
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Journal of Pharmacetical Sceiences Ewha Womans University
1992 Volume.2 No. 1 p.17 ~ p.32
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Ion-Exchange Albumin MC of Propranolol
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Abstract
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Empty cross-linked albumin microcapsules were prepared by chemical denaturation method using glutaraldehyde(GA) or terephthaloyl chloride(TP) as a cross-linking agent.
The binding efficiency of cross-linked albumin microcapsules was evaluated as a function of various conditions. Increasing of the concentrations of croos-linking agent, stirring time, the amount of microcapsules and the initial Propranolol HCI(PPH, HCI) concentration reduced the binding ability of these microcapsules. But the increasing of the mean particle diameter increase that of these microcapsules.
The release rates of PPH, HCI from the ion-exchange albumin microcapsules were retarded compared with the powder. And the total amount of drug released was dependent on the nature, the concentration of ionic strength of the cations used.
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